For men living with Peyronie’s disease, the development of penile curvature can create physical discomfort, emotional distress, and challenges with intimate relationships. Xiaflex® (collagenase clostridium histolyticum) offers a clinically proven, non-surgical approach to reducing curvature and improving quality of life—without the need for invasive surgery or general anesthesia.
Dr. Padra Gad Nourparvar is a board-certified physician with over a decade of experience in men’s health. His practice, located within the Cedars-Sinai Medical Office Towers in Los Angeles, provides Xiaflex injections as part of a comprehensive, individualized approach to Peyronie’s disease management. As a REMS-certified provider, Dr. Nourparvar has completed the specialized training required to safely administer this FDA-approved treatment.
The procedure went great and there was almost no pain. While in recovery the doctor was very responsive and helpful when it came to making sure my recovery went smoothly. Very Professional.
What Is Xiaflex®?
Xiaflex is the first and only FDA-approved non-surgical treatment for Peyronie’s disease in adult men with a palpable plaque and curvature of at least 30 degrees. The medication contains collagenase clostridium histolyticum—a specialized enzyme that works by breaking down the excess collagen that forms the Peyronie’s plaque. When injected directly into the plaque, Xiaflex helps dissolve the fibrous scar tissue responsible for penile curvature, allowing the body to gradually absorb and eliminate it over time.
How Xiaflex Treatment Works
Xiaflex therapy follows a structured treatment protocol administered over multiple cycles:
- Injection Sessions: each treatment cycle consists of two injections given one to three days apart, with the medication delivered directly into the Peyronie’s plaque
- Penile Modeling: one to three days after the second injection, Dr. Nourparvar performs an in-office modeling procedure—a manual stretching technique designed to help elongate the treated plaque and improve curvature correction
- Home Exercises: patients are instructed to perform daily penile stretching and straightening exercises at home for six weeks following each treatment cycle
- Multiple Cycles: up to four treatment cycles (eight total injections) may be administered, with at least six weeks between cycles to allow for tissue response and healing
“The combination of Xiaflex injections and the modeling procedure is what makes this treatment effective,” notes Dr. Nourparvar. “When patients commit to the full protocol, including their home exercises, we often see meaningful improvements in both curvature and overall satisfaction.”
Who Is a Candidate for Xiaflex?
Xiaflex is indicated for adult men with stable Peyronie’s disease who meet specific clinical criteria. Ideal candidates typically present with:
- Palpable Plaque: a distinct area of scar tissue that can be felt during physical examination
- Curvature of 30 Degrees or Greater: penile curvature that is significant enough to affect sexual function or cause distress
- Stable Disease: curvature that has not changed significantly over the past three months, indicating the condition has moved beyond the acute inflammatory phase
During your consultation, Dr. Nourparvar will conduct a thorough evaluation—including a detailed medical history and physical examination—to determine whether Xiaflex is the appropriate treatment for your condition.
What to Expect During Treatment
Xiaflex injections are performed in our private Los Angeles office within the Cedars-Sinai Medical Office Towers. The injection itself takes only a few minutes and is administered to the flaccid penis. Following the procedure, patients can return home the same day. Some swelling, bruising, or discomfort at the injection site is common and typically resolves within one to two weeks. Patients are advised to avoid sexual activity for at least two weeks after each injection and until any pain or swelling has subsided.
Frequently Asked Questions About Xiaflex Treatment
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Clinical trials demonstrated that approximately 75% of men treated with Xiaflex experienced at least a 25% improvement in curvature magnitude, with an average improvement of 17 degrees after up to four treatment cycles.
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Most patients experience some discomfort during the injection. Post-injection soreness, swelling, and bruising are common but typically manageable and resolve within one to two weeks.
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As with any medical procedure, Xiaflex carries potential risks including bruising, swelling, and pain at the injection site. In rare cases, more serious complications such as penile fracture have been reported, which is why Xiaflex is only available through a restricted REMS program administered by certified physicians.
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Most patients receive up to four treatment cycles, with each cycle consisting of two injections. Dr. Nourparvar will assess your progress after each cycle and discuss whether additional treatments are recommended.
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Xiaflex is designed to reduce curvature and improve symptoms rather than eliminate the condition entirely. Many patients experience significant improvement in both curvature and quality of life, though individual results vary.
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Many commercial insurance plans cover Xiaflex treatment for Peyronie’s disease. Our office can help verify your coverage and discuss financial options during your consultation.
Why Choose Dr. Nourparvar for Xiaflex Treatment
Patients throughout Los Angeles, Beverly Hills, Santa Monica, and beyond choose Dr. Nourparvar for his expertise, discretion, and commitment to personalized care. As a recipient of the UCLA Vice Provost Award and Motif Award for Advancement in Health, he brings both academic rigor and compassionate patient care to every treatment he provides. His practice within the Cedars-Sinai Medical Office Towers offers a private, hospital-adjacent environment where patients can feel confident in the quality and safety of their care.
Stem Cell & PRP Institute of L.A.
Premier center for regenerative medicine under the leadership of Dr. Padra Nourparvar, a nationally recognized, double board-certified physician with advanced medical training from UCLA, UC Irvine, NYU, and Mount Sinai, we specialize in cutting-edge stem cell therapies designed to restore function, reduce inflammation, and elevate long-term quality of life.
Dr. Nourparvar has received numerous accolades, including the UCLA Vice Provost Prize for Best Research Article of the Year and the Motif Award for Advancement of Health from The Walt Disney Company. With over a decade of experience treating conditions such as kidney failure, stroke, Parkinson’s disease, and more, he brings a rare combination of technical skill and human compassion to every patient encounter.
Schedule Your Xiaflex Consultation in Los Angeles
If you are living with Peyronie’s disease and are interested in exploring non-surgical treatment options, contact our Los Angeles office to schedule a confidential consultation. Dr. Nourparvar will evaluate your condition, discuss whether Xiaflex is right for you, and answer any questions you may have about the treatment process.